Disease Associated with Immune System – Section 1

1. The HIV virus infects primarily

A. brain cells
B. cells in the immune system
C. red blood cells
D. liver cells

Correct Answer: B. cells in the immune system

2. Chronic granulomatous disease results from a failure to perform the oxidative burst. This deficiency would be most likely to interfere with

A. CTL killing of viruses
B. dendritic cell activation to become a mature APC
C. infected cell processing of virus peptides
D. macrophage intracellular killing of bacteria

Correct Answer: D. macrophage intracellular killing of bacteria

3. Difficulties with somatic gene therapy arise from all of the following except

A. GVHD caused by mature T cells in the transplanted cells
B. inserting a gene so that it will function properly
C. limited life span of more mature hematopoietic cells
D. transducing genetic material into stem cells

Correct Answer: A. GVHD caused by mature T cells in the transplanted cells

4. A monoclonal antibody (mAb) specific for the 2,4-dinitrophenyl (DNP) hapten might also bind

A. Leu or Ileu
B. His or Pro
C. Tyr or Phe
D. Ser or Thr

Correct Answer: C. Tyr or Phe

5. Retinoblastoma is due to a mutation in a

A. kinase
B. tumor suppressor
C. cyclin
D. viral gene

Correct Answer: B. tumor suppressor

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