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Biochemistry
1. A 6-month-old boy is brought to the emergency department by his mother because of recent onset of vomiting, irritability, and jaundice. The infant was born at term and had been healthy until the onset of these symptoms. All of his vaccinations are up-to-date. He had been breast-fed exclusively until 1 week ago, when cereals and fruit juices were introduced into his diet. Further evaluation reveals hepatomegaly and abnormal liver function tests. Which of the following enzymes is most likely to be deficient in this patient?
A. Galactose-1-phosphate uridyl transferase
B. Aldolase B
C. Fructokinase
D. Galactokinase
E. Acid α-glucosidase
2. A 35-year-old man comes to the office with progressively worsening fatigue associated with dark urine and back pain. Two days ago, the patient ate some large, flat beans brought home by his wife after a business trip to Egypt. Physical examination shows jaundice and pallor. Laboratory results reveal a hemoglobin level of 8 g/dl . Further evaluation reveals deficiency of an enzyme involved in the conversion of glucose-6-phosphate to ribulose-5-phosphate. The substance generated during this conversion is necessary for which of the following biochemical processes?
A. ADP phosphorylation
B. Fatty acid synthesis
C. Glycogen storage
D. Ketone body synthesis
E. Protein degradation
3. A 64-year-old man comes to the emergency department due to severe abdominal pain, nausea, and vomiting. Medical history is significant for hypertension, myocardial infarction, and heart failure with reduced ejection fraction. The patient does not use alcohol but smokes a half-pack of cigarettes daily. Temperature is 37.6 C (99.7 F), blood pressure is 100/60 mm Hg, pulse is 116/min and irregular, and respirations are 24/min. The abdomen is soft, mildly distended, and mildly tender without rebound or guarding. Laboratory results are as follows:
CT angiography of the abdomen reveals an occlusion within the proximal superior mesenteric artery. Decreased activity of which of the following enzymes best explains this patient’s acid-base disorder?
A. Enolase
B. Lactate dehydrogenase
C. Pyruvate carboxylase
D. Pyruvate dehydrogenase
E. Pyruvate kinase