Free Online USMLE Step 1 Questions and Answers 1

10. Two graphs illustrating the transport rate of solutes across the plasma membrane are shown on the slide below.

Usmle1 4

Which of the following best explains the difference in the shape of the curves?

A. Different amounts of membrane surface area for diffusion
B. Different degrees of membrane thickness
C. The 2 solutes have different molecular weights
D. The 2 solutes have different oil/water partition coefficients
E. The presence of a protein transporter

Correct Answer: E

Answer Explanation:

(Choices A, B, C, D)
These other factors are important for determining the rate of diffusion (ie, slope of the line), but would not explain the flattening of the curve in line 1 (which is best accounted for by saturation of a protein carrier). In general, the rate of diffusion increases with:
• Higher concentration gradients across the membrane
• Lower molecular weight
• Larger diffusion surface area
• Thinner membrane thickness
For molecules that move through the membrane via simple diffusion, the degree of lipophilicity is also important; molecules with a high oil-water partition coefficient are more easily able to cross the membrane and will diffuse faster.

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