Allosteric Effects – Section 1

6. O2 binding to hemoglobin results in

A. 100-fold higher affinity for the last O2 bound than for the first
B. extensive protein conformational change
C. both (a) and (b)
D. 100-fold lower affinity for the last O2 bound than for the first

Correct Answer: C. both (a) and (b)

7. In hemoglobin, allosteric effects occur

A. only in humans
B. for maintaining Fe in the Fe2+ state
C. to minimize oxygen delivery to the tissues
D. to maximize oxygen delivery to the tissues

Correct Answer: D. to maximize oxygen delivery to the tissues

8. A protein that binds two ligands in a non-cooperative manner will show

A. a sigmodial binding curve
B. a hyperbolic binding curve
C. a linear Scatchard Plot
D. both (b) and (c)

Correct Answer: D. both (b) and (c)

9. Small molecules affect hemoglobin (Hb) by

A. decreasing Hb affinity for O2
B. increasing [H+] C. increasing Hb affinity for O2
D. increasing [H+] and decreasing Hb affinity for O2

Correct Answer: D. increasing [H+] and decreasing Hb affinity for O2

10. A protein that shows infinite cooperative for binding of n ligands will

A. show a Hill coefficient (nH) of 0.0
B. only be found in either the unliganded form or the fully liganded form
C. show a Hill coefficient (nH) of n
D. both (b) and (c)

Correct Answer: D. both (b) and (c)

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